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KMID : 0620920230550071357
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Experimental & Molecular Medicine
2023 Volume.55 No. 7 p.1357 ~ p.1370
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Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
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Xuemeng Xu
Qiu Peng
Xianjie Jiang
Shiming Tan
Yiqing Yang
Lee Jong-Ho
Yaqian Han
Yuyu Chen
Linda Oyang
Jinguan Lin
Longzheng Xia
Mingjing Peng
Nayiyuan Wu
Yanyan Tang
Jinyun Li
Qianjin Liao
Yujuan Zhou
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Abstract
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Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In cancer cells, metabolic pathway activity varies during tumorigenesis and cancer progression, indicating regulated metabolic plasticity. Metabolic changes are often closely related to epigenetic changes, such as alterations in the expression or activity of epigenetically modified enzymes, which may exert a direct or an indirect influence on cellular metabolism. Therefore, exploring the mechanisms underlying epigenetic modifications regulating the reprogramming of tumor cell metabolism is important for further understanding tumor pathogenesis. Here, we mainly focus on the latest studies on epigenetic modifications related to cancer cell metabolism regulations, including changes in glucose, lipid and amino acid metabolism in the cancer context, and then emphasize the mechanisms related to tumor cell epigenetic modifications. Specifically, we discuss the role played by DNA methylation, chromatin remodeling, noncoding RNAs and histone lactylation in tumor growth and progression. Finally, we summarize the prospects of potential cancer therapeutic strategies based on metabolic reprogramming and epigenetic changes in tumor cells.
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KEYWORD
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Biomarkers, Cancer metabolism
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